Restylane Lyft® is a similar material to Restylane®. Its difference lies in the size of the hyaluronic acid particles. In Restylane Lyft®. The particles are of a larger size. The increased size allows for deeper placement of the material and fill of deeper folds like the nasolabial folds or backs of the hands. Restylane Lyft® is injected in small amounts through either an ultra-fine needle or a blunt cannula. It is pre-mixed with lidocaine numbing medication, lessening any post-injection discomfort. Visit the Restylane® Silk page for an alternative option. Unlike Botox®, a Restylane Lyft® usually lasts about 9-12 months.